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A distinguishing feature of the successful “post‐Network Age” enterprise is its intrinsic entrepreneurial character that manifests itself in key organizational knowledge practices relating to organizational culture, processes, content and infrastructure. The purpose of this article is to explore organizational knowledge‐based practices.

The article reports on the outcome of field research in which entrepreneurial firms in four geographic regions were analyzed with the help of a diagnostic research tool specifically developed for profiling organizational knowledge‐based practices. The diagnostic tool was applied in firms located in Silicon Valley in the USA, Singapore, The Netherlands and Israel.

Key practices that were found to be common to leading‐edge firms in all regions included: a propensity for experimentation; collective sharing of knowledge, and collective decision making. The paper describes the research in terms of a cross‐cultural comparison of the four regions, derives key determinants of competitiveness, profiles regional characteristics which enhance innovation and entrepreneurship and closes with a discussion on the implications of the research outcomes for entrepreneurial firms seeking to build a global presence.

The research provides evidence that innovative, entrepreneurial firms – no matter where they are located – tend to exhibit organizational knowledge practices, cultural beliefs, values and behavioral norms that are more akin than dissimilar, regardless of national context.